Dr. Mohamed Abu-Farha

I am a Principal Scientist at Dasman Diabetes Institute (DDI) in Kuwait, where I lead the Proteomics Core Facility and head the Special Services Department. I hold a B.Sc. and M.Sc. from Carleton University in Canada and earned my Ph.D. from the University of Ottawa, followed by postdoctoral training at the Montreal Clinical Research Institute.
I am internationally recognized for my work in diabetes and metabolic diseases—particularly in lipid metabolism. I have authored over 144 peer-reviewed publications in leading journals such as Diabetes Care, JCEM, and Progress in Lipid Research, with over 4,400 citations and an h-index of 34. My team’s comprehensive characterization of ANGPTL8—particularly its role in lipid metabolism, adipose tissue regulation, and insulin-driven expression—has helped reshape our understanding of metabolic regulation and disease.
I currently lead multiple research projects focused on non-alcoholic fatty liver disease (NAFLD), diabetes prevention, and emerging therapies for type 1 diabetes. As an Adjunct Professor at the University of Texas at San Antonio, I have supervised graduate students, summer interns, and undergraduate researchers, while also contributing to teaching across all undergraduate levels. My commitment to mentorship and global collaboration reflects a strong dedication to advancing science and education.

• 2024 Scientist of the Year, Dasman Diabetes Institute
• 2022 Manager of the Year, Dasman Diabetes Institute
• Natural Sciences and Engineering Research Council (NSERC) of Canada Post-Doctoral Award – $80,000 (2011–2012)
• Ontario Graduate Scholarship – $30,000 (2006 and 2010)
• NSERC Canada Graduate Award – $63,000 (2006–2011)
• University of Ottawa Excellence Scholarship – $24,000 (2005–2010)
• Human Proteomic Organization Young Investigator Award – $600 (2009)
• Carleton University Master’s Admission Award – $32,000 (2003–2005)
• Carleton University Undergraduate Dean’s Scholarship – $5,000 (1999–2003)

List of Courses Taught at the University Level

• BIOL 1003 – Introductory Biology I, Carleton University, Ottawa, Canada
• BIOL 1004 – Introductory Biology II, Carleton University, Ottawa, Canada
• BIOC 2200 – Cell Physiology and Biochemistry, Carleton University, Ottawa, Canada
• BIOL 4109 – Laboratory Techniques in Molecular Genetics, Carleton University, Ottawa, Canada
• BCH3356 – Molecular Biology Lab (taught twice), University of Ottawa, Ottawa, Canada

• Co-supervision of three master's students at Kuwait University
• Over 10 years of experience teaching summer students as interns at Dasman Diabetes Institute
• Supervised Royal College of Surgeons in Ireland research projects, overseeing more than 10 students over five years
• Teaching Assistant for undergraduate courses at the University of Ottawa and Carleton University
• Lab Demonstrator for first-year biology, second- and third-year biochemistry and molecular biology, and fourth-year molecular biology courses
• Taught a mini-enrichment course for high school students at Carleton University
• Organized a two-day mass spectrometry course for graduate students at the University of Ottawa

• Kuwait Adult Diabetes and Epidemiologic Multidisciplinary (KADEM) Program
• Betatrophin a New Hope: Clinical and Biochemical Characterization of Betatrophin and its Role in Obesity and Diabetes (Principal Investigator)
• The role of ANGPTL8/Betatrophin in lipid metabolism and its association with other ANGPTL proteins and apolipoproteins (Principal Investigator)
• Impact of anti-diabetic medications on ANGPTL protein function in people with diabetes
• Deciphering the role of Betatrophin and its variants in beta-cell proliferation, lipid metabolism, and insulin signaling using metabolomics and proteomics (Principal Investigator)
• Contribution of glycation (AGEs/RAGE) signaling pathways to obesity and related complications in children (Principal Investigator)
• The role of HSP40 proteins in obesity and diabetes (Principal Investigator)
• The role of Betatrophin and HsCRP in the development of type 2 diabetes (Principal Investigator)
• Identification of OSA-related biomarkers and their relation to metabolic disorders (Co-Principal Investigator)
• Meteorin-like hormone as a potential regulator of obesity, diabetes, and energy expenditure (Co-Principal Investigator)
• Investigation of cellular and molecular anti-inflammatory response in obese individuals subjected to a defined exercise protocol
• Unraveling the role of micro-RNAs 103, 143, and 181 in obesity and diabetes
• High-resolution genetic analysis of type 1 diabetes
• Kuwait Diabetes Epidemiology Program: A population-based study of diabetes and obesity in Kuwait
• Investigating the effect of Liraglutide, a new incretin mimetic, on heat shock response (pilot study)
• Deciphering the role of Urocortin 3, a novel insulin secretion regulator, in diabetes
• Biological characterization of Kuwaiti-associated diabetes and obesity genes

• Can Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?
  Breakthrough T1D (formerly JDRF), $550,000 – Ongoing study
• Phase 2 Extension: Can Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?
  Breakthrough T1D (formerly JDRF), $350,000 – Ongoing study
• Effect of Pioglitazone on Inflammatory Response and Clinical Outcome in T2DM Patients With COVID-19
  Funded by Tabouk Pharmaceutical (drug contribution), $15,000
• Impact of Drug Treatment Using GLP1/GIP1 Agonist vs Bariatric Surgery on Insulin Signaling, Insulin Resistance, and Lipid Metabolism
  Funded by Johnson & Johnson, $20,000

• Use of MicroRNA-103 as an inhibitor for dyslipidemia by repressing the ANGPTL8 gene
• Use of MicroRNA-181D as an inhibitor for dyslipidemia by repressing the ANGPTL3 gene

• Docket No. 33060.88S – Identification of Protein Biomarkers for Diagnosis and Treatment Response in Sleep Apnea
  Inventors: Dr. Jehad Abubaker, Prof. Fahd Al-Mulla, Dr. Abdulmohsen Alterki, Dr. Mohamed Abu-Farha
• Docket No. 33060.89S – Identification of microRNA Biomarkers for Diagnosis and Treatment Response in Sleep Apnea
  Inventors: Dr. Jehad Abubaker, Prof. Fahd Al-Mulla, Dr. Abdulmohsen Alterki, Dr. Mohamed Abu-Farha
• Docket No. 33060.90S – Discovery and Application of Metabolic Biomarkers for Diagnosing Sleep Apnea and Predicting Treatment Response
  Inventors: Dr. Jehad Abubaker, Prof. Fahd Al-Mulla, Dr. Abdulmohsen Alterki, Dr. Mohamed Abu-Farha

• 84th American Diabetes Association Conference – Synergistic Effects of Dapagliflozin and Tirzepatide Combination Treatment on Weight Loss and Glucose Regulation in Diet-Induced Obese Animals
• 83rd American Diabetes Association Conference – Comparable Improvement in NAFLD, Weight Loss, and Lipid Metabolism in Rats Treated with Dual GLP-1–GIP Receptor Agonist (Tirzepatide) and Gastric Sleeve
• 83rd American Diabetes Association Conference – Adipocyte ANGPTL8 Regulates Insulin Sensitivity and Thermogenic Programming
• 82nd American Diabetes Association Conference – Plasma Insulin Is Required for the Increase in Plasma ANGPTL8 Concentration Following Glucose Ingestion

https://pubmed.ncbi.nlm.nih.gov/?term=abu-farha+M&sort=date

https://orcid.org/0000-0001-8357-1252

Scopus Author ID: 10045707200

1. Thanaraj, T.A., Abu-Farha, M., Albatineh, A.N., Channanath, A., Melhem, M., Chandy, B., Anoop, E., Abubaker, J., and Al-Mulla, F. (2025). Impact of Ethnicity on the Relationship Between Telomere Length and Metabolic Markers - a Multi-Ethnic Study from Kuwait. J Clin Endocrinol Metab.

2. Alshawaf, E., Marafie, S.K., Abu-Farha, M., Albatineh, A.N., Alramah, T., Albuhairi, A., Al Qassar, Y., Zinoun, R., Shalabi, R., Behbehani, S., et al. (2025). Circulating Isthmin-1 Levels and Their Relationship with Diabetes and Metabolic Diseases in Kuwaiti Adults. Biomedicines 13.

3. Almontashiri, N.A.M., Alharby, E., Saleh, M., Abu-Farha, M., Alasmari, A., Gebbia, M., Hiesl, C., Peake, R.W.A., Amr, S.S., Boles, E., et al. (2025). ME2 Deficiency Is Associated With Recessive Neurodevelopmental Disorder. Clin Genet 107, 201-207.

4. Yadikar, H., Ansari, M.A., Abu-Farha, M., Joseph, S., Thomas, B.T., and Al-Mulla, F. (2024). Deciphering Early and Progressive Molecular Signatures in Alzheimer's Disease through Integrated Longitudinal Proteomic and Pathway Analysis in a Rodent Model. Int J Mol Sci 25.

5. Roomy, M.A., Hussain, K., Behbehani, H.M., Abu-Farha, J., Al-Harris, R., Ambi, A.M., Abdalla, M.A., Al-Mulla, F., Abu-Farha, M., and Abubaker, J. (2024). Therapeutic advances in obesity management: an overview of the therapeutic interventions. Front Endocrinol (Lausanne) 15, 1364503.

6. Jacob, T., Sindhu, S., Hasan, A., Malik, M.Z., Arefanian, H., Al-Rashed, F., Nizam, R., Kochumon, S., Thomas, R., Bahman, F., et al. (2024). Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice. Front Microbiol 15, 1407258.

7. Ghosh, A., Chenier, I., Leung, Y.H., Oppong, A.K., Peyot, M.L., Madiraju, S.R.M., Al-Khairi, I., Abubaker, J., Al-Mulla, F., Prentki, M., et al. (2024). Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice. iScience 27, 111292.

8. Esaifan, H.A., Saadah, L.M., Abu Hammour, K., and Abu Farha, R.K. (2024). Machine learning assessment of vildagliptin and linagliptin effectiveness in type 2 diabetes: Predictors of glycemic control. PLoS One 19, e0309365.

9. Cherian, P., Al-Khairi, I., Abu-Farha, M., Alramah, T., Albatineh, A.N., Alhomaidah, D., Safadi, F., Ali, H., Abdul-Ghani, M., Tuomilehto, J., et al. (2024). Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Beta Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes. Biomedicines 12.

10. Baagar, K., Alessa, T., Abu-Farha, M., Abubaker, J., Alhumaidi, H., Franco Ceruto, J.A., Hamad, M.K., Omrani, A., Abdelrahman, S., Zaka-Ul Haq, M., et al. (2024). Effect of pioglitazone on inflammatory response and clinical outcome in T2DM patients with COVID-19: a randomized multicenter double-blind clinical trial. Front Immunol 15, 1369918.

11. Awwad, O., Abu Farha, R., Altaharwah, A., Sharaya, S., Naser, A.Y., and Tabaza, H. (2024). Acute COPD exacerbations and in-hospital treatment-related problems: An observational study. PLoS One 19, e0305011.

12. Arefanian, H., Al Madhoun, A., Al-Rashed, F., Alzaid, F., Bahman, F., Nizam, R., Alhusayan, M., John, S., Jacob, S., Williams, M.R., et al. (2024). Unraveling Verapamil's Multidimensional Role in Diabetes Therapy: From beta-Cell Regeneration to Cholecystokinin Induction in Zebrafish and MIN6 Cell-Line Models. Cells 13.

13. Alshawaf, E., Abu-Farha, M., Mohammad, A., Devarajan, S., Al-Khairi, I., Cherian, P., Ali, H., Al-Matrouk, H., Al-Mulla, F., Al Attar, A., et al. (2024). Angiopoietin-2 and Angiopoietin-like Proteins with a Prospective Role in Predicting Diabetic Nephropathy. Biomedicines 12.

14. Al-Sabah, S., Al-Khairi, I., Jamal, M., Qaddoumi, M., Alajmi, F., Kumar, J., Abukhalaf, N., Cherian, P., Madhu, D., Arefanian, H., et al. (2024). Effect of Dual GLP-1/GIP Receptor Agonist (Tirzepatide) Versus Bariatric Surgery on Weight Loss and NAFLD. Med Princ Pract.

15. Alramah, T., Cherian, P., Al-Khairi, I., Abu-Farha, M., Thanaraj, T.A., Albatineh, A.N., Safadi, F., Ali, H., Abdul-Ghani, M., Tuomilehto, J., et al. (2024). Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait. Front Endocrinol (Lausanne) 15, 1392675.

16. Al-Muhaiteeb, A., Alahmad, B., Abu-Farha, M., Abubaker, J., Thanaraj, T.A., Ali, H., Al-Mulla, F., and Qaddoumi, M. (2024). Long-Term Mortality and SGLT2 Inhibitors in Type 2 Diabetes with and without Renal Impairment: An Observational Cohort Study. Med Princ Pract 33, 251-259.

17. Ali, H., Malik, M.Z., Abu-Farha, M., Abubaker, J., Cherian, P., Nizam, R., Jacob, S., Bahbahani, Y., Naim, M., Ahmad, S., et al. (2024). Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease. The journal of gene medicine 26, e3674.

18. Ali, H., Malik, M.Z., Abu-Farha, M., Abubaker, J., Cherian, P., Al-Khairi, I., Nizam, R., Jacob, S., Bahbahani, Y., Al Attar, A., et al. (2024). Dysregulated Urinary Extracellular Vesicle Small RNAs in Diabetic Nephropathy: Implications for Diagnosis and Therapy. J Endocr Soc 8, bvae114.

19. Ali, H., Alahmad, B., Senum, S.R., Warsame, S., Bahbahani, Y., Abu-Farha, M., Abubaker, J., Alqaddoumi, M., Al-Mulla, F., and Harris, P.C. (2024). PKD1 Truncating Mutations Accelerate eGFR Decline in Autosomal Dominant Polycystic Kidney Disease Patients. Am J Nephrol 55, 380-388.

20. Alhaddad, M.E., Mohammad, A., Dashti, K.M., John, S.E., Bahbahani, Y., Abu-Farha, M., Abubaker, J., Thanaraj, T.A., Bastaki, L., Al-Mulla, F., et al. (2024). Genetic landscape and clinical outcomes of autosomal recessive polycystic kidney disease in Kuwait. Heliyon 10, e33898.

21. Abu-Farha, M., Benabdelkamel, H., Mazzotti, F., and Abdel Rahman, A.M. (2024). Editorial: Metabolomics in genetic and endocrinological diseases. Front Mol Biosci 11, 1365107.

22. Abdalla, M.A., Abubaker, J., Abu-Farha, M., Al-Khairi, I., Cherian, P., Qaddoumi, M.G., Al-Rashed, F., Thanaraj, T.A., Albatineh, A.N., and Al-Mulla, F. (2024). Investigating the Role of FABP4 in Diabetes and Obesity and the Influence of Age and Ethnicity: A Comprehensive Analysis of a Cohort from the KEDP-Study. Int J Mol Sci 25.

23. Rahman, A., Abu-Farha, M., Channanath, A., Hammad, M.M., Anoop, E., Chandy, B., Melhem, M., Al-Mulla, F., Thanaraj, T.A., and Abubaker, J. (2023). Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait. Front Endocrinol (Lausanne) 14, 1257051.

24. Poursharifi, P., Schmitt, C., Chenier, I., Leung, Y.H., Oppong, A.K., Bai, Y., Klein, L.L., Al-Mass, A., Lussier, R., Abu-Farha, M., et al. (2023). ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice. Mol Metab 78, 101822.

25. Marafie, S.K., Alshawaf, E., Abu-Farha, M., Thanaraj, T.A., Wei, D.Q., Al-Mulla, F., Khan, A., Abubaker, J., and Mohammad, A. (2023). Exploring the Binding Mechanism of NRG1-ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression. Interdiscip Sci 15, 452-464.

26. Leentjens, M., Bosschieter, P.F.N., Al-Terki, A., de Raaff, C.A.L., de Vries, C.E.E., Hammad, M., Thanaraj, T.A., Al-Khairi, I., Cherian, P., Channanath, A., et al. (2023). The association between biomarker angiopoietin-like protein five and obstructive sleep apnea in patients undergoing bariatric surgery. Sleep Breath 27, 1443-1454.

27. Iizuka, K., Yabe, D., Abu-Farha, M., Abubaker, J., and Al-Mulla, F. (2023). Editorial: Advances in the research of diabetic nephropathy, volume II. Front Endocrinol (Lausanne) 14, 1135265.

28. Hammad, M.M., Channanath, A.M., Abu-Farha, M., Rahman, A., Al Khairi, I., Cherian, P., Alramah, T., Alam-Eldin, N., Al-Mulla, F., Thanaraj, T.A., et al. (2023). Adolescent obesity and ANGPTL8: correlations with high sensitivity C-reactive protein, leptin, and chemerin. Front Endocrinol (Lausanne) 14, 1314211.

29. Hammad, M.M., Abu-Farha, M., Hebbar, P., Anoop, E., Chandy, B., Melhem, M., Channanath, A., Al-Mulla, F., Thanaraj, T.A., and Abubaker, J. (2023). The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians. Front Endocrinol (Lausanne) 14, 1185956.

30. Alterki, A., Abu-Farha, M., Al Shawaf, E., Al-Mulla, F., and Abubaker, J. (2023). Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases. Int J Mol Sci 24.

31. Al-Sabah, S., Jamal, M.H., Al-Khaledi, G., Dsouza, C., AlOtaibi, F.A., Al-Ali, W., Cherian, P., Al-Khairi, I., Ali, H., Abu-Farha, M., et al. (2023). Increased Glucagon Immunoreactivity in a Rat Model of Diet-induced Obesity following Sleeve Gastrectomy. Med Princ Pract 32, 232-241.

32. Al-Mulla, F., Alhomaidah, D., Abu-Farha, M., Hasan, A., Al-Khairi, I., Nizam, R., Alqabandi, R., Alkandari, H., and Abubaker, J. (2023). Early autoantibody screening for type 1 diabetes: a Kuwaiti perspective on the advantages of multiplexing chemiluminescent assays. Front Immunol 14, 1273476.

33. AlMajed, H.T., Abu-Farha, M., Alshawaf, E., Devarajan, S., Alsairafi, Z., Elhelaly, A., Cherian, P., Al-Khairi, I., Ali, H., Jose, R.M., et al. (2023). Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy. Int J Mol Sci 24.

34. Ali, H., Pinto, E.V.F., AlSahow, A., and Abu-Farha, M. (2023). Editorial: Advances in chronic kidney disease diagnosis and therapy. Front Med (Lausanne) 10, 1209571.

35. Ali, H., Naim, M., Senum, S.R., AlSahow, A., Bahbahani, Y., Abu-Farha, M., Abubaker, J., Mohammad, A., Al-Hunayan, A., Asbeutah, A.M., et al. (2023). The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait. Clin Kidney J 16, 355-366.

36. Ali, H., Abu-Farha, M., and Hofmann, S. (2023). Editorial: COVID-19 and diabetes, volume II. Front Endocrinol (Lausanne) 14, 1136997.

37. Alhammad, R., Abu-Farha, M., Rahman, A., Thanaraj, T.A., Shaban, L., Alsabah, R., Hamad, S., Hammad, M.M., Channanath, A., Al-Mulla, F., et al. (2023). LRG1 Associates with Iron Deficiency Anemia Markers in Adolescents. Nutrients 15.

38. Akhter, N., Wilson, A., Arefanian, H., Thomas, R., Kochumon, S., Al-Rashed, F., Abu-Farha, M., Al-Madhoun, A., Al-Mulla, F., Ahmad, R., et al. (2023). Endoplasmic Reticulum Stress Promotes the Expression of TNF-alpha in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1alpha and MAPK/NF-kappaB Pathways. Int J Mol Sci 24.

39. Abu-Farha, M., Madhu, D., Hebbar, P., Mohammad, A., Channanath, A., Kavalakatt, S., Alam-Eldin, N., Alterki, F., Taher, I., Alsmadi, O., et al. (2023). The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-kappaB Signaling Pathway under TNFalpha Stimulation. Cells 12.

40. Abu-Farha, M., Joseph, S., Mohammad, A., Channanath, A., Taher, I., Al-Mulla, F., Mujammami, M., Thanaraj, T.A., Abubaker, J., and Abdel Rahman, A.M. (2023). Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant. Metabolites 13.

41. Abu-Farha, M., Alatrach, M., Abubaker, J., Al-Khairi, I., Cherian, P., Agyin, K., Abdelgani, S., Norton, L., Adams, J., Al-Saeed, D., et al. (2023). Plasma insulin is required for the increase in plasma angiopoietin-like protein 8 in response to nutrient ingestion. Diabetes Metab Res Rev 39, e3643.

42. Abdelgani, S., Khattab, A., Adams, J., Abu-Farha, M., Daniele, G., Al-Mulla, F., Del Prato, S., DeFronzo, R.A., and Abdul-Ghani, M. (2023). Distinct Mechanisms Responsible for the Increase in Glucose Production and Ketone Formation Caused by Empagliflozin in T2DM Patients. Diabetes Care 46, 978-984.

43. Shehab, M., Alrashed, F., Alfadhli, A., Alsayegh, A., Aldallal, U., Alsayegh, M., Cherian, P., Alkhair, I., Thanaraj, T.A., Channanath, A., et al. (2022). Immunogenicity of BNT162b2 Vaccine Booster Dose in Patients With Inflammatory Bowel Disease Receiving Infliximab Combination Therapy: A Prospective Observational Study. Front Med (Lausanne) 9, 933996.

44. Shehab, M., Alrashed, F., Abdullah, I., Alfadhli, A., Ali, H., Abu-Farha, M., Channanath, A.M., Abubaker, J.A., and Al-Mulla, F. (2022). Impact of BNT162b2 mRNA Vaccination on the Development of Short and Long-Term Vaccine-Related Adverse Events in Inflammatory Bowel Disease: A Multi-Center Prospective Study. Front Med (Lausanne) 9, 881027.

45. Qaddoumi, M., Hebbar, P., Abu-Farha, M., Al Somaly, A., Melhem, M., Al-Kayal, F., AlKhairi, I., Cherian, P., Alanbaei, M., Al-Mulla, F., et al. (2022). GALNT2 rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level. Genes (Basel) 13.

46. Oguoma, V.M., Coffee, N.T., Alsharrah, S., Abu-Farha, M., Al-Refaei, F.H., Alkandari, A., Al-Mulla, F., and Daniel, M. (2022). Anthropometric cut-points for discriminating diabetes and the metabolic syndrome among Arabs and Asians: the Kuwait Diabetes Epidemiology Program - CORRIGENDUM. Br J Nutr 128, 160.

47. Oguoma, V.M., Abu-Farha, M., Coffee, N.T., Alsharrah, S., Al-Refaei, F.H., Abubaker, J., Daniel, M., and Al-Mulla, F. (2022). Metabolically Healthy and Unhealthy Obese Phenotypes among Arabs and South Asians: Prevalence and Relationship with Cardiometabolic Indicators. Nutrients 14.

48. Leentjens, M., Alterki, A., Abu-Farha, M., Bosschieter, P.F.N., de Raaff, C., de Vries, C., Al Shawaf, E., Thanaraj, T.A., Al-Khairi, I., Cherian, P., et al. (2022). Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity. Front Endocrinol (Lausanne) 13, 922425.

49. Jamal, M.H., AlOtaibi, F., Dsouza, C., Al-Sabah, S., Al-Khaledi, G., Al-Ali, W., Ali, H., Cherian, P., Al-Khairi, I., Devarajan, S., et al. (2022). Changes in the expression of meteorin-like (METRNL), irisin (FNDC5), and uncoupling proteins (UCPs) after bariatric surgery. Obesity (Silver Spring) 30, 1629-1638.

50. Hoteit, M., Mortada, H., Al-Jawaldeh, A., Mansour, R., Yazbeck, B., AlKhalaf, M., Bookari, K., Tayyem, R., Al-Awwad, N.J., Al Sabbah, H., et al. (2022). Dietary Diversity in the Eastern Mediterranean Region Before and During the COVID-19 Pandemic: Disparities, Challenges, and Mitigation Measures. Front Nutr 9, 813154.

51. Hasan, A., Arefanian, H., Channanath, A.M., AlKhairi, I., Cherian, P., Devarajan, S., Thanaraj, T.A., Abu-Farha, M., Abubaker, J., and Al-Mulla, F. (2022). Association of COVID-19 Vaccines ChAdOx1-S and BNT162b2 with Circulating Levels of Coagulation Factors and Antithrombin. Vaccines (Basel) 10.

52. Hammad, M.M., Mohammad, A., Alam-Eldin, N., Madhu, D., Al-Mulla, F., Abu-Farha, M., and Abubaker, J. (2022). Structural analysis of setmelanotide binding to MC4R variants in comparison to wild-type receptor. Life Sci 307, 120857.

53. Baskaradoss, J.K., Tavares, M., Al-Mulla, F., Al-Ozairi, E., Abu-Farha, M., Bin-Hasan, S., Alsumait, A., Devarajan, S., and Alqaderi, H. (2022). Association between Frequency of Toothbrushing and Metabolic Syndrome among Adolescents: A 5-Year Follow-Up Study. Int J Environ Res Public Health 19.

54. Alqaderi, H., Hegazi, F., Al-Mulla, F., Chiu, C.J., Kantarci, A., Al-Ozairi, E., Abu-Farha, M., Bin-Hasan, S., Alsumait, A., Abubaker, J., et al. (2022). Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents. Front Public Health 10, 800373.

55. Ali, H., Abu-Farha, M., Hammad, M.M., Devarajan, S., Bahbahani, Y., Al-Khairi, I., Cherian, P., Alsairafi, Z., Vijayan, V., Al-Mulla, F., et al. (2022). Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy. Front Endocrinol (Lausanne) 13, 882700.

56. Ali, H., Abu-Farha, M., Alshawaf, E., Devarajan, S., Bahbahani, Y., Al-Khairi, I., Cherian, P., Alsairafi, Z., Vijayan, V., Al-Mulla, F., et al. (2022). Association of significantly elevated plasma levels of NGAL and IGFBP4 in patients with diabetic nephropathy. BMC Nephrol 23, 64.

57. Alhammad, R., Abu-Farha, M., Hammad, M.M., Thanaraj, T.A., Channanath, A., Alam-Eldin, N., Al-Sabah, R., Shaban, L., Alduraywish, A., Al-Mulla, F., et al. (2022). Increased LRG1 Levels in Overweight and Obese Adolescents and Its Association with Obesity Markers, Including Leptin, Chemerin, and High Sensitivity C-Reactive Protein. Int J Mol Sci 23.

58. Alhamar, G., Maddaloni, E., Al Shukry, A., Al-Sabah, S., Al-Haddad, M., Al-Youha, S., Jamal, M., Almazeedi, S., Al-Shammari, A.A., Abu-Farha, M., et al. (2022). Development of a clinical risk score to predict death in patients with COVID-19. Diabetes Metab Res Rev 38, e3526.

59. Al Sabbah, H., Taha, Z., Qasrawi, R., Assaf, E.A., Cheikh Ismail, L., Al Dhaheri, A.S., Hoteit, M., Al-Jawaldeh, A., Tayyem, R., Bawadi, H., et al. (2022). The Impact of COVID-19 on Physical (In)Activity Behavior in 10 Arab Countries. Int J Environ Res Public Health 19.

60. Al Madhoun, A., Hebbar, P., Nizam, R., Haddad, D., Melhem, M., Abu-Farha, M., Thanaraj, T.A., and Al-Mulla, F. (2022). Caveolin-1 rs1997623 variant and adult metabolic syndrome-Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians. Front Genet 13, 1034892.

61. Abu-Farha, M., Lee, Y.H., and Abubaker, J. (2022). Editorial: Pharmacology and treatment methods for NAFLD in the context of diabetes. Front Endocrinol (Lausanne) 13, 1010485.

62. Abu-Farha, M., Iizuka, K., Yabe, D., Al-Mulla, F., and Abubaker, J. (2022). Editorial: Advances in the research of diabetic nephropathy. Front Endocrinol (Lausanne) 13, 1116188.

63. Abu-Farha, M., Hofmann, S., and Ali, H. (2022). Editorial: Covid-19 and Diabetes. Front Endocrinol (Lausanne) 13, 933562.

64. Taher, I., Almaeen, A., Ghazy, A., Abu-Farha, M., Mohamed Channanath, A., Elsa John, S., Hebbar, P., Arefanian, H., Abubaker, J., Al-Mulla, F., et al. (2021). Relevance between COVID-19 and host genetics of immune response. Saudi J Biol Sci 28, 6645-6652.

65. Shehab, M., Alrashed, F., Alfadhli, A., Alotaibi, K., Alsahli, A., Mohammad, H., Cherian, P., Al-Khairi, I., Alphonse Thanaraj, T., Channanath, A., et al. (2021). Serological Response to BNT162b2 and ChAdOx1 nCoV-19 Vaccines in Patients with Inflammatory Bowel Disease on Biologic Therapies. Vaccines (Basel) 9.

66. Shehab, M., Abu-Farha, M., Alrashed, F., Alfadhli, A., Alotaibi, K., Alsahli, A., Alphonse Thanaraj, T., Channanath, A., Ali, H., Abubaker, J., et al. (2021). Immunogenicity of BNT162b2 Vaccine in Patients with Inflammatory Bowel Disease on Infliximab Combination Therapy: A Multicenter Prospective Study. J Clin Med 10.

67. Rahman, A., Hammad, M.M., Al Khairi, I., Cherian, P., Al-Sabah, R., Al-Mulla, F., Abu-Farha, M., and Abubaker, J. (2021). Profiling of Insulin-Like Growth Factor Binding Proteins (IGFBPs) in Obesity and Their Association With Ox-LDL and Hs-CRP in Adolescents. Front Endocrinol (Lausanne) 12, 727004.

68. Oguoma, V.M., Coffee, N.T., Alsharrah, S., Abu-Farha, M., Al-Refaei, F.H., Al-Mulla, F., and Daniel, M. (2021). Prevalence of overweight and obesity, and associations with socio-demographic factors in Kuwait. BMC Public Health 21, 667.

69. Mohammad, A., Alshawaf, E., Marafie, S.K., Abu-Farha, M., Al-Mulla, F., and Abubaker, J. (2021). Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10-nsp16 Complex of SARS-CoV-2. Biomolecules 11.

70. Mohammad, A., Alshawaf, E., Marafie, S.K., Abu-Farha, M., Abubaker, J., and Al-Mulla, F. (2021). Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity. Int J Infect Dis 103, 611-616.

71. Hebbar, P., Abu-Farha, M., Abubaker, J., Channanath, A.M., Al-Mulla, F., and Thanaraj, T.A. (2021). Generalizability of GWA-Identified Genetic Risk Variants for Metabolic Traits to Populations from the Arabian Peninsula. Genes (Basel) 12.

72. Hebbar, P., Abubaker, J.A., Abu-Farha, M., Alsmadi, O., Elkum, N., Alkayal, F., John, S.E., Channanath, A., Iqbal, R., Pitkaniemi, J., et al. (2021). Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population. Hum Genet 140, 505-528.

73. Cherian, P., Al-Khairi, I., Jamal, M., Al-Sabah, S., Ali, H., Dsouza, C., Alshawaf, E., Al-Ali, W., Al-Khaledi, G., Al-Mulla, F., et al. (2021). Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity. Front Endocrinol (Lausanne) 12, 752892.

74. Arefanian, H., Al-Khairi, I., Khalaf, N.A., Cherian, P., Kavalakatt, S., Madhu, D., Mathur, A., Qaddoumi, M.G., Al-Mulla, F., Abubaker, J., et al. (2021). Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment. Lipids Health Dis 20, 117.

75. Alterki, A., Al Shawaf, E., Al-Khairi, I., Cherian, P., Sriraman, D., Hammad, M., Thanaraj, T.A., Ebrahim, M.A.K., Al-Mulla, F., Abu-Farha, M., et al. (2021). The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels. Dis Markers 2021, 1219593.

76. Alshukry, A., Bu Abbas, M., Ali, Y., Alahmad, B., Al-Shammari, A.A., Alhamar, G., Abu-Farha, M., AbuBaker, J., Devarajan, S., Dashti, A.A., et al. (2021). Clinical characteristics and outcomes of COVID-19 patients with diabetes mellitus in Kuwait. Heliyon 7, e06706.

77. Al-Sayegh, M., Ali, H., Jamal, M.H., ElGindi, M., Chanyong, T., Al-Awadi, K., and Abu-Farha, M. (2021). Mouse Embryonic Fibroblast Adipogenic Potential: A Comprehensive Transcriptome Analysis. Adipocyte 10, 1-20.

78. Al-Mulla, F., Mohammad, A., Al Madhoun, A., Haddad, D., Ali, H., Eaaswarkhanth, M., John, S.E., Nizam, R., Channanath, A., Abu-Farha, M., et al. (2021). ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19. Heliyon 7, e06133.

79. Ali, H., Alterki, A., Sindhu, S., Alahmad, B., Hammad, M., Al-Sabah, S., Alghounaim, M., Jamal, M.H., Aldei, A., Mairza, M.J., et al. (2021). Robust Antibody Levels in Both Diabetic and Non-Diabetic Individuals After BNT162b2 mRNA COVID-19 Vaccination. Front Immunol 12, 752233.

80. Ali, H., Alshukry, A., Marafie, S.K., AlRukhayes, M., Ali, Y., Abbas, M.B., Al-Taweel, A., Bukhamseen, Y., Dashti, M.H., Al-Shammari, A.A., et al. (2021). Outcomes of COVID-19: Disparities by ethnicity. Infect Genet Evol 87, 104639.

81. Ali, H., Alahmad, B., Al-Shammari, A.A., Alterki, A., Hammad, M., Cherian, P., Alkhairi, I., Sindhu, S., Thanaraj, T.A., Mohammad, A., et al. (2021). Previous COVID-19 Infection and Antibody Levels After Vaccination. Front Public Health 9, 778243.

82. Alanbaei, M., Abu-Farha, M., Hebbar, P., Melhem, M., Chandy, B.S., Anoop, E., Cherian, P., Al-Khairi, I., Alkayal, F., Al-Mulla, F., et al. (2021). ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals. Genes (Basel) 12.

83. Abu-Farha, M., Tuomilehto, J., and Abubaker, J. (2021). Editorial: Diabetes in the Middle East. Front Endocrinol (Lausanne) 12, 638653.

84. Qaddoumi, M.G., Alanbaei, M., Hammad, M.M., Al Khairi, I., Cherian, P., Channanath, A., Thanaraj, T.A., Al-Mulla, F., Abu-Farha, M., and Abubaker, J. (2020). Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes. Sci Rep 10, 6170.

85. Mohammad, A., Marafie, S.K., Alshawaf, E., Abu-Farha, M., Abubaker, J., and Al-Mulla, F. (2020). Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2. Life Sci 259, 118219.

86. Jamal, M.H., Abu-Farha, M., Al-Khaledi, G., Al-Sabah, S., Ali, H., Cherian, P., Al-Khairi, I., AlOtaibi, F., Al-Ali, W., Bosso, M., et al. (2020). Effect of sleeve gastrectomy on the expression of meteorin-like (METRNL) and Irisin (FNDC5) in muscle and brown adipose tissue and its impact on uncoupling proteins in diet-induced obesity rats. Surg Obes Relat Dis 16, 1910-1918.

87. Hebbar, P., Abu-Farha, M., Alkayal, F., Nizam, R., Elkum, N., Melhem, M., John, S.E., Channanath, A., Abubaker, J., Bennakhi, A., et al. (2020). Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population. Sci Rep 10, 152.

88. Hammad, M.M., Abu-Farha, M., Hebbar, P., Cherian, P., Al Khairi, I., Melhem, M., Alkayal, F., Alsmadi, O., Thanaraj, T.A., Al-Mulla, F., et al. (2020). MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort. Front Endocrinol (Lausanne) 11, 437.

89. Hammad, M.M., Abu-Farha, M., Al-Taiar, A., Alam-Eldin, N., Al-Sabah, R., Shaban, L., Al-Mulla, F., Abubaker, J., and Rahman, A. (2020). Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents. Sci Rep 10, 6330.

90. Bosso, M., Thanaraj, T.A., Abu-Farha, M., Alanbaei, M., Abubaker, J., and Al-Mulla, F. (2020). The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19. Mol Ther Methods Clin Dev 18, 321-327.

91. Alterki, A., Joseph, S., Thanaraj, T.A., Al-Khairi, I., Cherian, P., Channanath, A., Sriraman, D., Ebrahim, M.A.K., Ibrahim, A., Tiss, A., et al. (2020). Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery. Metabolites 10.

92. Alshukry, A., Ali, H., Ali, Y., Al-Taweel, T., Abu-Farha, M., AbuBaker, J., Devarajan, S., Dashti, A.A., Bandar, A., Taleb, H., et al. (2020). Clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Kuwait. PLoS One 15, e0242768.

93. Alqaderi, H., Al-Ozairi, E., Bin-Hasan, S., Tavares, M., Goodson, J.M., Alsumait, A., Abu-Farha, M., Abubaker, J., Devarajan, S., Almuhana, N., et al. (2020). Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents. Biomark Med 14, 1427-1437.

94. Alkandari, A., Alarouj, M., Elkum, N., Sharma, P., Devarajan, S., Abu-Farha, M., Al-Mulla, F., Tuomilehto, J., and Bennakhi, A. (2020). Adult Diabetes and Prediabetes Prevalence in Kuwait: Data from the Cross-Sectional Kuwait Diabetes Epidemiology Program. J Clin Med 9.

95. Al Madhoun, A., Marafie, S.K., Haddad, D., Melhem, M., Abu-Farha, M., Ali, H., Sindhu, S., Atari, M., and Al-Mulla, F. (2020). Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells. Int J Mol Sci 21.

96. Abu-Farha, M., Thanaraj, T.A., Qaddoumi, M.G., Hashem, A., Abubaker, J., and Al-Mulla, F. (2020). The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target. Int J Mol Sci 21.

97. Abu-Farha, M., Ghosh, A., Al-Khairi, I., Madiraju, S.R.M., Abubaker, J., and Prentki, M. (2020). The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation. Prog Lipid Res 80, 101067.

98. Abu-Farha, M., Al-Sabah, S., Hammad, M.M., Hebbar, P., Channanath, A.M., John, S.E., Taher, I., Almaeen, A., Ghazy, A., Mohammad, A., et al. (2020). Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism. Front Pharmacol 11, 587451.

99. Abu-Farha, M., Al-Mulla, F., Thanaraj, T.A., Kavalakatt, S., Ali, H., Abdul Ghani, M., and Abubaker, J. (2020). Impact of Diabetes in Patients Diagnosed With COVID-19. Front Immunol 11, 576818.

100. Abdel-Halim, S.M., Al Madhoun, A., Nizam, R., Melhem, M., Cherian, P., Al-Khairi, I., Haddad, D., Abu-Farha, M., Abubaker, J., Bitar, M.S., et al. (2020). Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study. Biology (Basel) 9.

101. Sindhu, S., Thomas, R., Kochumon, S., Wilson, A., Abu-Farha, M., Bennakhi, A., Al-Mulla, F., and Ahmad, R. (2019). Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation. Cells 8.

102. Nizam, R., Al-Ozairi, E., Goodson, J.M., Melhem, M., Davidsson, L., Alkhandari, H., Al Madhoun, A., Shamsah, S., Qaddoumi, M., Alghanim, G., et al. (2019). Corrigendum: Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children. Front Genet 10, 221.

103. Kochumon, S., Al-Rashed, F., Abu-Farha, M., Devarajan, S., Tuomilehto, J., and Ahmad, R. (2019). Adipose tissue expression of CCL19 chemokine is positively associated with insulin resistance. Diabetes Metab Res Rev 35, e3087.

104. Hebbar, P., Abu-Farha, M., Mohammad, A., Alkayal, F., Melhem, M., Abubaker, J., Al-Mulla, F., and Thanaraj, T.A. (2019). FTO Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population. Front Genet 10, 1411.

105. Hebbar, P., Abubaker, J.A., Abu-Farha, M., Tuomilehto, J., Al-Mulla, F., and Thanaraj, T.A. (2019). A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations. Front Endocrinol (Lausanne) 10, 8.

106. AlKhairi, I., Cherian, P., Abu-Farha, M., Madhoun, A.A., Nizam, R., Melhem, M., Jamal, M., Al-Sabah, S., Ali, H., Tuomilehto, J., et al. (2019). Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin. Cells 8.

107. Ali, H., Al-Mulla, F., Hussain, N., Naim, M., Asbeutah, A.M., AlSahow, A., Abu-Farha, M., Abubaker, J., Al Madhoun, A., Ahmad, S., et al. (2019). PKD1 Duplicated regions limit clinical Utility of Whole Exome Sequencing for Genetic Diagnosis of Autosomal Dominant Polycystic Kidney Disease. Sci Rep 9, 4141.

108. Alghanim, G., Qaddoumi, M.G., Alhasawi, N., Cherian, P., Al-Khairi, I., Nizam, R., Alkayal, F., Alanbaei, M., Tuomilehto, J., Abubaker, J., et al. (2019). Higher Levels of ANGPTL5 in the Circulation of Subjects With Obesity and Type 2 Diabetes Are Associated With Insulin Resistance. Front Endocrinol (Lausanne) 10, 495.

109. Al Shawaf, E., Abu-Farha, M., Devarajan, S., Alsairafi, Z., Al-Khairi, I., Cherian, P., Ali, H., Mathur, A., Al-Mulla, F., Al Attar, A., et al. (2019). ANGPTL4: A Predictive Marker for Diabetic Nephropathy. J Diabetes Res 2019, 4943191.

110. Abu-Farha, M., Cherian, P., Al-Khairi, I., Nizam, R., Alkandari, A., Arefanian, H., Tuomilehto, J., Al-Mulla, F., and Abubaker, J. (2019). Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3. Sci Rep 9, 11866.

111. Nizam, R., Al-Ozairi, E., Goodson, J.M., Melhem, M., Davidsson, L., Alkhandari, H., Al Madhoun, A., Shamsah, S., Qaddoumi, M., Alghanim, G., et al. (2018). Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children. Front Genet 9, 689.

112. Cherian, P.T., Al-Khairi, I., Sriraman, D., Al-Enezi, A., Al-Sultan, D., AlOtaibi, M., Al-Enezi, S., Tuomilehto, J., Al-Mulla, F., Abubaker, J.A., et al. (2018). Increased Circulation and Adipose Tissue Levels of DNAJC27/RBJ in Obesity and Type 2-Diabetes. Front Endocrinol (Lausanne) 9, 423.

113. Al-Terki, A., Abu-Farha, M., AlKhairi, I., Cherian, P.T., Sriraman, D., Shyamsundar, A., Ali, S., Almulla, F., Tuomilehto, J., and Abubaker, J.A. (2018). Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea. Front Endocrinol (Lausanne) 9, 651.

114. Abu-Farha, M., Cherian, P., Qaddoumi, M.G., AlKhairi, I., Sriraman, D., Alanbaei, M., and Abubaker, J. (2018). Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension. Lipids Health Dis 17, 35.

115. Melhem, M., Abu-Farha, M., Antony, D., Madhoun, A.A., Bacchelli, C., Alkayal, F., AlKhairi, I., John, S., Alomari, M., Beales, P.L., et al. (2017). Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia. Eur J Haematol 98, 218-227.

116. Abu-Farha, M., Cherian, P., Al-Khairi, I., Madhu, D., Tiss, A., Warsam, S., Alhubail, A., Sriraman, D., Al-Refaei, F., and Abubaker, J. (2017). Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise. PLoS One 12, e0173024.

117. Abu-Farha, M., Abubaker, J., and Tuomilehto, J. (2017). ANGPTL8 (betatrophin) role in diabetes and metabolic diseases. Diabetes Metab Res Rev 33.

118. Khadir, A., Kavalakatt, S., Abubaker, J., Cherian, P., Madhu, D., Al-Khairi, I., Abu-Farha, M., Warsame, S., Elkum, N., Dehbi, M., et al. (2016). Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone. Metabolism 65, 1409-1420.

119. Baothman, O.A., Zamzami, M.A., Taher, I., Abubaker, J., and Abu-Farha, M. (2016). The role of Gut Microbiota in the development of obesity and Diabetes. Lipids Health Dis 15, 108.

120. Abu-Farha, M., Sriraman, D., Cherian, P., AlKhairi, I., Elkum, N., Behbehani, K., and Abubaker, J. (2016). Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training. PLoS One 11, e0147367.

121. Abu-Farha, M., Melhem, M., Abubaker, J., Behbehani, K., Alsmadi, O., and Elkum, N. (2016). ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits. Lipids Health Dis 15, 26.

122. Abu-Farha, M., Al-Khairi, I., Cherian, P., Chandy, B., Sriraman, D., Alhubail, A., Al-Refaei, F., AlTerki, A., and Abubaker, J. (2016). Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D. Lipids Health Dis 15, 181.

123. Abu-Farha, M., Al Madhoun, A., and Abubaker, J. (2016). The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer of beta-Cell Proliferation. J Diabetes Res 2016, 4860595.

124. Abu-Farha, M., Abubaker, J., Al-Khairi, I., Cherian, P., Noronha, F., Kavalakatt, S., Khadir, A., Behbehani, K., Alarouj, M., Bennakhi, A., et al. (2016). Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome. Cardiovasc Diabetol 15, 25.

125. Khadir, A., Tiss, A., Abubaker, J., Abu-Farha, M., Al-Khairi, I., Cherian, P., John, J., Kavalakatt, S., Warsame, S., Al-Madhoun, A., et al. (2015). MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise. Am J Physiol Endocrinol Metab 308, E71-83.

126. Ali, H., Al-Yatama, M.K., Abu-Farha, M., Behbehani, K., and Al Madhoun, A. (2015). Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers. PLoS One 10, e0122465.

127. Abu-Farha, M., Cherian, P., Al-Khairi, I., Tiss, A., Khadir, A., Kavalakatt, S., Warsame, S., Dehbi, M., Behbehani, K., and Abubaker, J. (2015). DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression. Sci Rep 5, 14448.

128. Abu-Farha, M., Behbehani, K., and Elkum, N. (2015). High adiponectin levels in lean Arab women compared to Asian women. Biomark Res 3, 7.

129. Abu-Farha, M., Abubaker, J., Noronha, F., Al-Khairi, I., Cherian, P., Alarouj, M., Bennakhi, A., and Elkum, N. (2015). Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects. Cardiovasc Diabetol 14, 112.

130. Abu-Farha, M., Abubaker, J., Al-Khairi, I., Cherian, P., Noronha, F., Hu, F.B., Behbehani, K., and Elkum, N. (2015). Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance. Sci Rep 5, 10949.

131. Tiss, A., Khadir, A., Abubaker, J., Abu-Farha, M., Al-Khairi, I., Cherian, P., John, J., Kavalakatt, S., Warsame, S., Al-Ghimlas, F., et al. (2014). Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue. Lipids Health Dis 13, 106.

132. Baturcam, E., Abubaker, J., Tiss, A., Abu-Farha, M., Khadir, A., Al-Ghimlas, F., Al-Khairi, I., Cherian, P., Elkum, N., Hammad, M., et al. (2014). Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans. Mediators Inflamm 2014, 627150.

133. Abu-Farha, M., Dehbi, M., Noronha, F., Tiss, A., Alarouj, M., Behbehani, K., Bennakhi, A., and Elkum, N. (2014). Gender differences in ghrelin association with cardiometabolic risk factors in arab population. Int J Endocrinol 2014, 730472.

134. Abu-Farha, M., Behbehani, K., and Elkum, N. (2014). Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. Cardiovasc Diabetol 13, 76.

135. Abu-Farha, M., Tiss, A., Abubaker, J., Khadir, A., Al-Ghimlas, F., Al-Khairi, I., Baturcam, E., Cherian, P., Elkum, N., Hammad, M., et al. (2013). Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. PLoS One 8, e75342.

136. Abubaker, J., Tiss, A., Abu-Farha, M., Al-Ghimlas, F., Al-Khairi, I., Baturcam, E., Cherian, P., Elkum, N., Hammad, M., John, J., et al. (2013). DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise. PLoS One 8, e69217.

137. Zhou, H., Ning, Z., Starr, A.E., Abu-Farha, M., and Figeys, D. (2012). Advancements in top-down proteomics. Anal Chem 84, 720-734.

138. Ning, Z., Zhou, H., Wang, F., Abu-Farha, M., and Figeys, D. (2011). Analytical aspects of proteomics: 2009-2010. Anal Chem 83, 4407-4426.

139. Abu-Farha, M., Lanouette, S., Elisma, F., Tremblay, V., Butson, J., Figeys, D., and Couture, J.F. (2011). Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2. J Mol Cell Biol 3, 301-308.

140. Abu-Farha, M., Elisma, F., Zhou, H., Tian, R., Zhou, H., Asmer, M.S., and Figeys, D. (2009). Proteomics: from technology developments to biological applications. Anal Chem 81, 4585-4599.

141. Abu-Farha, M., Lambert, J.P., Al-Madhoun, A.S., Elisma, F., Skerjanc, I.S., and Figeys, D. (2008). The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. Mol Cell Proteomics 7, 560-572.

142. Abu-Farha, M., Elisma, F., and Figeys, D. (2008). Identification of protein-protein interactions by mass spectrometry coupled techniques. Adv Biochem Eng Biotechnol 110, 67-80.

143. Ewing, R.M., Chu, P., Elisma, F., Li, H., Taylor, P., Climie, S., McBroom-Cerajewski, L., Robinson, M.D., O'Connor, L., Li, M., et al. (2007). Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3, 89.

144. Abu-Farha, M., Niles, J., and Willmore, W.G. (2005). Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition. Biochem Cell Biol 83, 620-630.